Methylcytosine Dioxygenase (TET2) Antibody
416€ (200 µl)
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935106861
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name
Methylcytosine Dioxygenase (TET2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431638
tested applications
P-ELISA, IHC, FCM
Description
TET2 Antibody is a Goat Polyclonal antibody against TET2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Methylcytosine Dioxygenase (TET2) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/16000, IHC: 2-6 µg/ml, FCM: 10 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 54790, 214133 |
| NCBI Accession | NP_001120680.1, NP_060098.3 |
| Alias | IMD75,KIAA1546,MDS |
| Background | Antibody anti-TET2 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
TET2 is a member of the TET family of dioxygenases that catalyzes the conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) in DNA, promoting active DNA demethylation and epigenetic regulation. TET2 is widely expressed in hematopoietic cells and plays a critical role in stem cell self-renewal, differentiation, and lineage commitment. It acts as a tumor suppressor by maintaining genomic stability and ensuring proper gene expression patterns, particularly in hematopoiesis. Loss-of-function mutations in TET2 are frequently observed in myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and other hematological malignancies, where they disrupt DNA methylation balance, alter gene regulation, and promote uncontrolled proliferation. TET2 also regulates immune responses by modulating T cell differentiation and inflammatory gene expression. Knockout studies in mice demonstrate enhanced hematopoietic stem cell self-renewal, impaired differentiation, and increased susceptibility to leukemogenesis, emphasizing TET2's role in DNA methylation dynamics, tumor suppression, and immune regulation.
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