Metalloproteinase Inhibitor 1 (TIMP1) Antibody Pair
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Description
Timp1 Antibody Pair for use in Sandwich ELISA assay development. This antibody pair contains the capture antibody and the detection antibody necessary to prepare five 96-well ELISA kit plates.
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Product specifications
| Category | Antibody Pairs |
| Immunogen Target | Metalloproteinase Inhibitor 1 (TIMP1) |
| Reactivity | Rabbit, Rat |
| Assay Data | Capture: Mouse IgG1 Monoclonal Detection: Mouse IgG1 Monoclonal (Biotin) |
| Assay Type | Sandwich |
| Size 1 | 5 × 96 tests |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | Tissue inhibitor of metalloproteinases 1,EPA,EPO,HCI,CLGI,TIMP,TIMP-1 |
| Background | Antibody Pair for TIMP1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
TIMP1 is a member of the TIMP family and acts as a natural inhibitor of matrix metalloproteinases (MMPs), which are enzymes that degrade components of the extracellular matrix TIMP1 regulates tissue remodeling, inflammation, and wound healing by inhibiting MMP activity and preventing excessive matrix breakdown It also exhibits anti-apoptotic properties by binding to cell surface receptors and activating survival pathways TIMP1 plays a role in cancer progression where its overexpression can inhibit tumor invasion and metastasis by limiting MMP activity, while paradoxically, it can also promote tumor growth by stimulating cell proliferation and angiogenesis Dysregulation of TIMP1 is observed in diseases such as fibrosis, cardiovascular disease, and chronic inflammatory conditions, where altered MMP activity contributes to tissue damage and remodeling TIMP1’s dual role as a regulator of extracellular matrix turnover and cell signaling makes it a key player in both normal physiological processes and pathological conditions
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