Metabotropic Glutamate Receptor 4 (GRM4) Cell ELISA Kit
513.5€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Metabotropic Glutamate Receptor 4 (GRM4) Cell ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx595382
Tested Applications
ELISA
Description
mGluR4 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Metabotropic Glutamate Receptor 4 (GRM4) |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q14833 |
| Gene ID | 2914 |
| OMIM | 604100 |
| Alias | GRM4,GPRC1D,MGLUR4,mGlu4 |
| Background | Elisa Kits for: GRM4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Background
GRM4, or mGluR4, belongs to the Group III metabotropic glutamate receptors and primarily couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cyclic AMP (cAMP) levels. GRM4 is predominantly expressed in the cerebellum, basal ganglia, and thalamus, where it functions as a presynaptic receptor to suppress excessive glutamate release. It plays a critical role in regulating synaptic plasticity, motor coordination, and neuronal excitability. GRM4 activation has neuroprotective effects, reducing excitotoxicity and inflammation in neurological conditions. Dysregulation of GRM4 has been associated with Parkinson’s disease, anxiety, and chronic pain, where impaired glutamate signaling contributes to disease pathology. GRM4 agonists are being investigated as therapeutic agents for Parkinson’s disease, as they modulate basal ganglia circuitry and improve motor symptoms. Additionally, GRM4’s role in neuroprotection and reducing inflammation makes it a promising target for treating neurodegenerative diseases, chronic pain, and psychiatric disorders.
Productos relacionados
Glutamate Metabotropic Receptor 4 (GRM4) Antibody
GRM4 Antibody is a Rabbit Polyclonal antibody against GRM4. L-glutamate is the major excitatory neurotransmitter in the …
Ver producto
Metabotropic Glutamate Receptor 4 (GRM4) Antibody
Metabotropic Glutamate Receptor 4 (GRM4) Antibody is a Rabbit Polyclonal antibody for the detection of GRM4.…
Ver producto
Glutamate Metabotropic Receptor 4 (GRM4) Antibody
GRM4 Antibody is a Rabbit Polyclonal against GRM4.…
Ver producto