Membrane Cofactor Protein (CD46) Antibody (PE)
234€ (25 tests)
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Name
Membrane Cofactor Protein (CD46) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx413724
Tested Applications
FCM
Description
Cluster of Differentiation 46 (CD46) Antibody (PE) is a Mouse Monoclonal antibody against Cluster of Differentiation 46 (CD46).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Membrane Cofactor Protein (CD46) |
| Host | Mouse |
| Reactivity | Human |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 25 tests |
| Size 2 | 100 tests |
| Form | Lyophilized |
| Tested Applications | FCM |
| Buffer | PBS, 1% BSA. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15529 |
| Alias | MCP,TLX,AHUS2,MIC10,TRA2.10,Membrane cofactor protein,Trophoblast leukocyte common antigen |
| Background | Antibody anti-CD46 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD46, also known as membrane cofactor protein (MCP), is a transmembrane glycoprotein that serves primarily as a regulatory component of the complement system, protecting host cells from complement-mediated damage. CD46 is widely expressed on almost all nucleated cells and plays a key role in immune regulation, ensuring that the complement system, which is responsible for clearing pathogens, does not attack the body’s own cells. CD46 does this by serving as a cofactor for the proteolytic cleavage of C3b and C4b, two crucial components of the complement pathway, which are inactivated by factor I. In addition to its role in the complement system, CD46 is involved in various immune functions, including modulation of T-cell responses, immune tolerance, and viral entry. Several viruses, such as the measles virus and human herpesvirus 6 (HHV-6), use CD46 as a receptor to gain entry into host cells, highlighting its involvement in viral pathogenesis.
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