MELTF Antibody

Background

Melanotransferrin (MELTF) is a cell-surface glycoprotein belonging to the transferrin family of iron-binding proteins, which also includes serum transferrin and lactoferrin. Unlike these other transferrins, which circulate in blood plasma or bodily secretions to transport iron, MELTF is primarily membrane-bound. Initially identified in melanoma cells, MELTF is now known to be widely expressed on the cell surface of a variety of tissues and has been implicated in cellular iron metabolism and immune functions. This protein is of particular interest in oncology and neurodegenerative research, as its overexpression has been observed in certain cancers and neurodegenerative diseases. The primary role of MELTF is thought to involve iron binding and cellular iron transport, but its full range of functions is not completely understood. Due to its structure and iron-binding capabilities, MELTF is believed to play roles in oxidative stress response and iron homeostasis, both crucial for maintaining cellular function and mitigating the damage caused by reactive oxygen species (ROS). The protein is also being studied for its potential role in cancer cell proliferation, migration, and angiogenesis