Melatonin Receptor 1B (MTNR1B) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Melatonin Receptor 1B (MTNR1B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432995
tested applications
P-ELISA, IHC
Description
MTNR1B Antibody is a Goat Polyclonal antibody against MTNR1B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Melatonin Receptor 1B (MTNR1B) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4544 |
| NCBI Accession | NP_005950.1 |
| Alias | MTNR1B,mel1b receptor |
| Background | Antibody anti-MTNR1B |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
MTNR1B, also known as MT2, is a G protein-coupled receptor for melatonin, expressed in the retina, pancreas, and central nervous system. Like MTNR1A, MTNR1B inhibits adenylate cyclase activity through Gi proteins, reducing cAMP levels and modulating circadian rhythms, sleep regulation, and metabolic processes. MTNR1B plays a critical role in glucose metabolism by regulating insulin secretion in pancreatic β-cells, where melatonin signaling affects insulin release and glucose homeostasis. Genetic variants in MTNR1B have been strongly associated with an increased risk of type 2 diabetes, highlighting its role in impaired glucose tolerance and β-cell dysfunction. In the retina, MTNR1B helps regulate photoreceptor sensitivity and circadian rhythms, contributing to visual function. Dysregulation of MTNR1B signaling has been linked to sleep disturbances, metabolic disorders, and impaired glucose regulation. MTNR1B is being explored as a therapeutic target for managing type 2 diabetes, circadian rhythm disorders, and sleep-related conditions, emphasizing its dual role in metabolic and circadian regulation.
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