Melanocortin Receptor 5 (MC5R) Antibody
416€ (200 µl)
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935106861
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name
Melanocortin Receptor 5 (MC5R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431422
tested applications
P-ELISA, WB, IHC
Description
MC5R Antibody is a Goat Polyclonal antibody against MC5R.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Melanocortin Receptor 5 (MC5R) |
| Host | Goat |
| Reactivity | Human, Mouse |
| Recommended Dilution | P-ELISA: 1/8000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4161, 17203 |
| NCBI Accession | NP_005904.1 |
| Alias | MC5R,MC2,melanocortin receptor 5 |
| Background | Antibody anti-MC5R |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
MC5R is a G protein-coupled receptor activated by melanocortins, including α-MSH and ACTH. It is widely expressed in various peripheral tissues, including the skin, adrenal glands, and exocrine glands. MC5R regulates the production of sebaceous lipids in sebaceous glands, contributing to skin and hair lubrication and barrier function. It also influences inflammatory responses, immune regulation, and steroidogenesis. In immune cells, MC5R activation suppresses pro-inflammatory cytokine production, highlighting its role in anti-inflammatory processes. Dysregulation of MC5R has been implicated in skin disorders such as acne, where altered lipid production disrupts skin homeostasis. MC5R may also play a role in regulating energy metabolism, muscle growth, and thermogenesis. Therapeutically, MC5R agonists are being explored for their potential in treating inflammatory skin conditions, metabolic dysfunction, and immune-related disorders. Its diverse roles in lipid production, inflammation, and tissue homeostasis make MC5R a promising target for skin and metabolic therapies.
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