Melanocortin Receptor 4 (MC4R) Antibody
292.5€ (200 µl)
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name
Melanocortin Receptor 4 (MC4R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432950
tested applications
P-ELISA
Description
MC4R Antibody is a Goat Polyclonal antibody against MC4R.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Melanocortin Receptor 4 (MC4R) Immunogen: abx617075 - N-Terminus: NSTHRGMHTSLH-C |
| Host | Goat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4160 |
| NCBI Accession | NP_005903.2 |
| Alias | MC4R,BMIQ20 |
| Background | Antibody anti-MC4R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
MC4R is a G protein-coupled receptor activated by melanocortins such as α-MSH and ACTH, primarily expressed in the hypothalamus. MC4R plays a central role in regulating energy homeostasis, appetite suppression, and body weight. Activation of MC4R stimulates Gs proteins, increasing intracellular cAMP levels and activating downstream pathways to inhibit feeding and promote energy expenditure. Mutations in MC4R are the most common cause of monogenic obesity, resulting in hyperphagia and reduced energy expenditure. In addition to its role in metabolism, MC4R influences glucose homeostasis, cardiovascular function, and sexual behavior. MC4R agonists are being developed as potential therapeutics for obesity and related metabolic disorders, while antagonists are explored for cachexia and anorexia. MC4R’s critical role in appetite regulation and energy balance highlights its significance as a target for treating obesity, metabolic syndrome, and weight-related disorders.
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