Melanocortin Receptor 4 (MC4R) Antibody

Product specifications

Primary Antibodies

Melanocortin Receptor 4 (MC4R)

Goat

P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

200 µl

Liquid

P-ELISA

Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

4160

NP_005903.2

MC4R,BMIQ20

Antibody anti-MC4R

RUO

Concentration: 0.5 mg/ml - 

Descripción

MC4R is a G protein-coupled receptor activated by melanocortins such as α-MSH and ACTH, primarily expressed in the hypothalamus. MC4R plays a central role in regulating energy homeostasis, appetite suppression, and body weight. Activation of MC4R stimulates Gs proteins, increasing intracellular cAMP levels and activating downstream pathways to inhibit feeding and promote energy expenditure. Mutations in MC4R are the most common cause of monogenic obesity, resulting in hyperphagia and reduced energy expenditure. In addition to its role in metabolism, MC4R influences glucose homeostasis, cardiovascular function, and sexual behavior. MC4R agonists are being developed as potential therapeutics for obesity and related metabolic disorders, while antagonists are explored for cachexia and anorexia. MC4R’s critical role in appetite regulation and energy balance highlights its significance as a target for treating obesity, metabolic syndrome, and weight-related disorders.

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