Melanocortin 5 Receptor (MC5R) Antibody (Biotin)
169€ (20 µg)
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Name
Melanocortin 5 Receptor (MC5R) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx336476
Tested Applications
ELISA
Description
MC5R Antibody (Biotin) is a Rabbit Polyclonal against MC5R.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Melanocortin 5 Receptor (MC5R) Immunogen: Recombinant Human Melanocortin receptor 5 protein (1-37AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P33032 |
| Gene ID | 4161 |
| Alias | MC5R,MC2,melanocortin receptor 5 |
| Background | Antibody anti-MC5R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
MC5R is a G protein-coupled receptor activated by melanocortins, including α-MSH and ACTH. It is widely expressed in various peripheral tissues, including the skin, adrenal glands, and exocrine glands. MC5R regulates the production of sebaceous lipids in sebaceous glands, contributing to skin and hair lubrication and barrier function. It also influences inflammatory responses, immune regulation, and steroidogenesis. In immune cells, MC5R activation suppresses pro-inflammatory cytokine production, highlighting its role in anti-inflammatory processes. Dysregulation of MC5R has been implicated in skin disorders such as acne, where altered lipid production disrupts skin homeostasis. MC5R may also play a role in regulating energy metabolism, muscle growth, and thermogenesis. Therapeutically, MC5R agonists are being explored for their potential in treating inflammatory skin conditions, metabolic dysfunction, and immune-related disorders. Its diverse roles in lipid production, inflammation, and tissue homeostasis make MC5R a promising target for skin and metabolic therapies.
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