Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) Antibody
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Description
MAP4K2 Antibody is a Rabbit Polyclonal against MAP4K2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q12851 |
| Gene ID | 5871 |
| OMIM | 603166 |
| Background | Antibody anti-MAP4K2 |
| Status | RUO |
Descripción
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MAP4K2 antibody
Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase(MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase(SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns(PAMPs) such as polyinosine-polycytidine(poly(IC)), lipopolysaccharides(LPS), lipid A, peptidoglycan(PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.
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