Matrix Metalloproteinase 9 (MMP9) Antibody

Este producto es parte de MMP9-Matrix Metalloproteinase 9

Pida mas información

935106861

info@markelab.com

Precio

337.5€ (100 µg)

proveedor

Abbexa

reference

abx037932

Tested Applications

ELISA, IHC

reactivity

Human, Rat

status

RUO

clonality

Polyclonal

Descripción

Rabbit Polyclonal against the MMP9 protein.

Background

MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. MMP-9, alternatively known as 92 kDa type IV collagenase, 92 kDa gelatinase, or gelatinase B (GELB), belongs to the zinc-metalloproteinases within the Matrixin family. In humans, the MMP-9 gene is responsible for encoding this enzyme. MMP-9's substrates include gelatin and collagen types IV and V. This gelatinase, MMP-9, has been associated with various medical conditions, including the development of atherosclerosis, chronic obstructive pulmonary disease (COPD), tumor formation, metastasis, and wound repair

Background

MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. MMP-9, también conocida como colagenasa tipo IV de 92 kDa, gelatinasa de 92 kDa o gelatinasa B (GELB), pertenece a las metaloproteinasas de zinc dentro de la familia Matrixin. En humanos, el gen MMP-9 es el responsable de codificar esta enzima. Los sustratos de MMP-9 incluyen gelatina y colágeno de tipos IV y V. Esta gelatinasa, MMP-9, se ha asociado con diversas afecciones médicas, incluido el desarrollo de aterosclerosis, enfermedad pulmonar obstructiva crónica (EPOC), formación de tumores, metástasis y reparación de heridas

Características del producto

clonality

Polyclonal

reactivity

Human, Rat

immunogen target

Matrix Metalloproteinase 9 (MMP9)

host

Rabbit

conjugation

Unconjugated

form

Lyophilized

tested applications

ELISA, IHC

purification

Purified by antigen affinity column chromatography.

buffer

Prior to lyophilization: 1% BSA and 0.02% NaN3.

size 1

100 µg

storage

Store at -20 °C. Avoid repeated freeze/thaw cycles.

or code

MMP9

dry ice

availability

Shipped within 7-15 working days.

alias

GELB,CLG4B,MMP-9,MANDP2,92 kDa type IV collagenase, Gelatinase B

NCBI accession

NP_004985

note

This product is for research use only.

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