Matrix Metalloproteinase-9 (MMP9) Antibody
195€ (20 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Matrix Metalloproteinase-9 (MMP9) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx001707
Tested Applications
ELISA, WB
Description
MMP9 Antibody is a Rabbit Polyclonal antibody against MMP9. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Matrix Metalloproteinase-9 (MMP9) Immunogen: Synthetic peptide corresponding to MMP9. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2.40 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 78 kDa Observed MW: 100/84 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P14780 |
| Gene ID | 4318 |
| NCBI Accession | NP_004985.2 |
| OMIM | 120361 |
| Alias | GELB,CLG4B,MMP-9,MANDP2,92 kDa type IV collagenase, Gelatinase B |
| Background | Antibody anti-MMP9 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Matrix metalloproteinase 9 (MMP9), also known as gelatinase B, is an enzyme belonging to the matrix metalloproteinase family. MMP-9 is a zinc-dependent endopeptidase. It is synthesized as a proenzyme, and requires activation by other proteases to become active. The active form of MMP-9 can degrade various components of the extracellular matrix, including collagen type IV, which is a major component of the basement membrane. MMP-9 is implicated in several physiological and pathological processes, including tissue remodeling, angiogenesis, wound healing, inflammation, and cancer metastasis. It is involved in the breakdown of the extracellular matrix, which is essential for processes like tissue repair and remodeling. However, dysregulation of MMP-9 activity can contribute to pathological conditions such as excessive tissue degradation, tumor invasion, and metastasis.MMP-9 activity is tightly regulated at multiple levels, including transcriptional regulation, post-translational modification, and inhibition by tissue inhibitors of metalloproteinases (TIMPs)
Productos relacionados
Matrix Metalloproteinase-9 (MMP9) Antibody
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ph…
Ver producto
Human Matrix Metalloproteinase-9 (MMP9) ELISA Kit
Human Matrix Metalloproteinase-9 (MMP9) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human MMP…
Ver producto
Matrix Metalloproteinase-9 (MMP9) Antibody
Matrix Metalloproteinase-9 (MMP9) Antibody is a Mouse Monoclonal antibody against Human Matrix Metalloproteinase-9 (MMP9…
Ver producto