Stromelysin-1 Antibody (HRP) is a Rabbit Polyclonal antibody against Stromelysin-1 conjugated to HRP.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Stromelysin-1, also recognized as matrix metalloproteinase-3 (MMP-3), is an enzyme encoded by the MMP3 gene in humans. Aliases are: CHDS6, MMP-3, SL-1, STMY, STMY1, and STR1.This enzyme plays a significant role in the degradation of fibronectin, laminin, as well as collagens III, IV, IX, and X, along with cartilage proteoglycans. MMP-3 is involved in various biological processes such as wound repair, the progression of atherosclerosis, and the initiation of tumors.
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. La estromelisina-1, también reconocida como metaloproteinasa de matriz-3 (MMP-3), es una enzima codificada por el gen MMP3 en humanos. Los alias son: CHDS6, MMP-3, SL-1, STMY, STMY1 y STR1. Esta enzima juega un papel importante en la degradación de la fibronectina, la laminina, así como los colágenos III, IV, IX y X, junto con el cartílago. proteoglicanos. MMP-3 participa en diversos procesos biológicos, como la reparación de heridas, la progresión de la aterosclerosis y la iniciación de tumores.
Primary Antibodies
Polyclonal
Human
Matrix Metalloproteinase 3 / Stromelysin-1 (MMP3)
Rabbit
HRP
Liquid
ELISA
> 95%
Purified by Protein G.
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
20 µg
50 µg
100 µg
200 µg
1 mg
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
MMP3
No
Shipped within 5-10 working days.
This product is for research use only.
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