Matrix Metalloproteinase 1 (MMP1) Antibody (HRP)

Pida mas información

935106861

info@markelab.com

Precio

162.5€ (20 µg)

proveedor

Abbexa

reference

abx108434

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Interstitial collagenase Antibody (HRP) is a Rabbit Polyclonal antibody against Interstitial collagenase conjugated to HRP.

Background

MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Interstitial collagenase, also recognized as matrix metalloproteinase-1 (MMP-1), is an enzyme encoded by the MMP1 gene in humans. This enzyme, when secreted, serves to degrade interstitial collagens, including types I, II, and III. It is also known by aliases such as CLG and CLGN

Background

MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. La colagenasa intersticial, también reconocida como metaloproteinasa de matriz-1 (MMP-1), es una enzima codificada por el gen MMP1 en humanos. Esta enzima, cuando se secreta, sirve para degradar los colágenos intersticiales, incluidos los tipos I, II y III. También se le conoce con alias como CLG y CLGN

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Matrix Metalloproteinase 1 (MMP1)

host

Rabbit

conjugation

HRP

form

Liquid

tested applications

ELISA

purity

> 95%

purification

Purified by Protein G.

buffer

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.

size 1

20 µg

size 2

50 µg

size 3

100 µg

size 4

200 µg

size 5

1 mg

storage

Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.

or code

MMP1

dry ice

availability

Shipped within 5-10 working days.

uniprot id

https://www.uniprot.org/uniprotkb/P03956

gene id

https://www.ncbi.nlm.nih.gov/gene/4312

note

This product is for research use only.

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proveedor

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reference

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Tested Applications

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status

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