Matrix Metalloproteinase 1 (MMP1) Antibody
proveedor
Abbexareference
abx037450Tested Applications
ELISA, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Rabbit Polyclonal against the MMP1 protein.
Background
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Interstitial collagenase, also recognized as matrix metalloproteinase-1 (MMP-1), is an enzyme encoded by the MMP1 gene in humans. This enzyme, when secreted, serves to degrade interstitial collagens, including types I, II, and III. It is also known by aliases such as CLG and CLGN
Background
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. La colagenasa intersticial, también reconocida como metaloproteinasa de matriz-1 (MMP-1), es una enzima codificada por el gen MMP1 en humanos. Esta enzima, cuando se secreta, sirve para degradar los colágenos intersticiales, incluidos los tipos I, II y III. También se le conoce con alias como CLG y CLGN
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Matrix Metalloproteinase 1 (MMP1)
host
Rabbit
conjugation
Unconjugated
form
Lyophilized
tested applications
ELISA, IHC
purification
Purified by antigen affinity column chromatography.
buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
size 1
100 µg
storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
or code
MMP1
dry ice
No
availability
Shipped within 7-15 working days.
NCBI accession
NM_002421
note
This product is for research use only.
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