Matrix Metalloproteinase 1 (MMP1) Antibody

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935106861

info@markelab.com

Precio

337.5€ (100 µg)

proveedor

Abbexa

reference

abx037450

Tested Applications

ELISA, IHC

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Rabbit Polyclonal against the MMP1 protein.

Background

MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Interstitial collagenase, also recognized as matrix metalloproteinase-1 (MMP-1), is an enzyme encoded by the MMP1 gene in humans. This enzyme, when secreted, serves to degrade interstitial collagens, including types I, II, and III. It is also known by aliases such as CLG and CLGN

Background

MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. La colagenasa intersticial, también reconocida como metaloproteinasa de matriz-1 (MMP-1), es una enzima codificada por el gen MMP1 en humanos. Esta enzima, cuando se secreta, sirve para degradar los colágenos intersticiales, incluidos los tipos I, II y III. También se le conoce con alias como CLG y CLGN

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Matrix Metalloproteinase 1 (MMP1)

host

Rabbit

conjugation

Unconjugated

form

Lyophilized

tested applications

ELISA, IHC

purification

Purified by antigen affinity column chromatography.

buffer

Prior to lyophilization: 1% BSA and 0.02% NaN3.

size 1

100 µg

storage

Store at -20 °C. Avoid repeated freeze/thaw cycles.

or code

MMP1

dry ice

availability

Shipped within 7-15 working days.

NCBI accession

NM_002421

note

This product is for research use only.

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proveedor

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reference

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reactivity

rat

status

RUO

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