Mannose Receptor C Type 2 (MRC2) Antibody
377€ (100 µg)
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Name
Mannose Receptor C Type 2 (MRC2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx147058
Tested Applications
ELISA, WB
Description
Mannose Receptor C Type 2 (MRC2) Antibody is a Rabbit Polyclonal antibody for the detection of CD280.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Mannose Receptor C Type 2 (MRC2) Immunogen: MRC2 |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 190 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UBG0 |
| Gene ID | 9902 |
| OMIM | 612264 |
| Alias | C-type mannose receptor 2,CD280,UPARAP,CLEC13E,ENDO180,C-type lectin domain family 13 member E,Endocytic receptor 180,UPAR-associated protein |
| Background | Antibody anti-MRC2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Mannose receptor C-type 2 (MRC2), also known as endocytic mannose receptor or uPARAP/Endo180, is a transmembrane glycoprotein receptor and a member of the C-type lectin family. MRC2 plays a significant role in the cellular processes of endocytosis and extracellular matrix (ECM) remodeling, particularly through binding and internalizing glycoproteins and matrix components. MRC2 is predominantly expressed in cells with endocytic functions, including fibroblasts, macrophages, and endothelial cells, and contributes to tissue homeostasis, immune response, and wound healing by modulating cellular uptake of glycosylated and collagenous materials. MRC2 is one of several mannose receptors, structurally distinct from others such as MRC1. Unlike MRC1, which is primarily involved in antigen capture and immune surveillance, MRC2 is most notable for its role in collagen uptake and degradation, positioning it as a unique player in matrix remodeling and turnover. The receptor's collagen-binding capacity has been linked to its role in tumor progression and metastasis in cancer as well as in fibrosis, where excessive ECM accumulation disrupts normal tissue function.
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