Macrophage Mannose Receptor 1 (MRC1) Antibody (FITC)

Este producto es parte de MRC1 - mannose receptor C-type 1
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169€ (20 µg)

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935106861
info@markelab.com
name
Macrophage Mannose Receptor 1 (MRC1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx304532

Description

MRC1 Antibody (FITC) is a Rabbit Polyclonal against MRC1 conjugated to FITC.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Macrophage Mannose Receptor 1 (MRC1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
FITC
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P22897
Gene ID
4360
NCBI Accession
NP_002429.1, NM_002438.3
OMIM
153618
Alias
Macrophage mannose receptor 1,MMR,hMR,CD206,MRC1L1,CLEC13D; CLEC13DL,C-type lectin domain family 13 member D,C-type lectin domain family 13 member D-like,Macrophage mannose receptor 1-like protein 1
Background
Antibody anti-MRC1
Status
RUO

Descripción

MRC1, or mannose receptor C-type 1, is a type I transmembrane protein predominantly found on the surface of macrophages, dendritic cells, and certain endothelial cells. The receptor, encoded by the MRC1 gene, plays an essential role in immune surveillance and host defense against pathogens. It is a member of the C-type lectin receptor (CLR) family, a group of proteins involved in recognizing carbohydrate structures on pathogens, facilitating their capture, and subsequently initiating immune responses. The mannose receptor (MR) recognizes and binds to mannose, fucose, and N-acetylglucosamine residues, which are common on the surface of microorganisms, thereby enabling the immune system to detect a broad range of pathogens, including bacteria, fungi, and viruses. This recognition mechanism is crucial for identifying foreign pathogens that display distinct glycosylation patterns on their surfaces compared to host cells. Beyond its role in pathogen recognition, MRC1 is involved in various physiological processes, including antigen processing and presentation, phagocytosis, and homeostasis. By mediating endocytosis of specific ligands and facilitating the clearance of glycoproteins and degraded cell components, MRC1 supports tissue repair and cellular turnover, making it integral to both innate immunity and tissue remodeling.

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