Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) Antibody
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935106861
info@markelab.com
Precio
275€ (0.1 mg)
Antibody anti-LAMP1
proveedor
Abbexareference
abx139700Tested Applications
WB, IHC, IF/ICC, FCMreactivity
Human, Monkey, Mousestatus
RUOclonality
MonoclonalDescripción
CD107a Antibody (Azide free) is a Mouse Monoclonal against CD107a.
Background
Lysosome-associated membrane glycoprotein 1 (LAMP1) is a transmembrane protein located on the lysosomal membrane that plays a key role in lysosome integrity, autophagy, and cellular homeostasis LAMP1 is highly expressed in cells undergoing autophagy, where it contributes to lysosomal stability and fusion with autophagosomes for the degradation of cellular waste It is involved in lysosome exocytosis, which regulates plasma membrane repair, pathogen clearance, and cellular stress responses LAMP1 also serves as a marker for lysosomal activity and has been implicated in immune responses, particularly in natural killer (NK) cell-mediated cytotoxicity Dysregulation of LAMP1 expression has been observed in neurodegenerative diseases such as Parkinson’s and Alzheimer’s, where impaired lysosomal function leads to protein aggregation and cellular toxicity Additionally, LAMP1 overexpression is associated with cancer progression and metastasis, where it facilitates cellular invasion through lysosome-mediated extracellular matrix degradation Its role in maintaining lysosomal function underscores its importance in cellular health and disease pathology
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human, Monkey, Mouse
immunogen target
Lysosome-Associated Membrane Glycoprotein 1 (LAMP1)
host
Mouse
conjugation
Unconjugated
tested applications
WB, IHC, IF/ICC, FCM
purity
> 95% (SDS-PAGE)
purification
Purified by Protein A affinity chromatography.
buffer
Azide free PBS, approx. pH 7.4; 0.2 µm filter sterilized.
size 1
0.1 mg
storage
Store at 2-8°C. Do not freeze.
or code
LAMP1
dry ice
No
availability
Shipped within 5-12 working days.
alias
LAMPA,CD107a,LGP120,CD107 antigen-like family member A
uniprot id
note
This product is for research use only.
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