Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) Antibody
299€ (0.1 mg)
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935106861
info@markelab.com
name
Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139700
tested applications
WB, IHC, IF/ICC, FCM
Description
CD107a Antibody (Azide free) is a Mouse Monoclonal against CD107a.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) |
| Host | Mouse |
| Reactivity | Human, Monkey, Mouse |
| Recommended Dilution | WB: 1 μg/ml, IHC: 2-8 μg/ml, FCM: 1-12 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | N743 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IHC, IF/ICC, FCM |
| Buffer | Azide free PBS, approx. pH 7.4; 0.2 µm filter sterilized. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P11279 |
| Gene ID | 3916 |
| Alias | LAMPA,CD107a,LGP120,CD107 antigen-like family member A |
| Background | Antibody anti-LAMP1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Lysosome-associated membrane glycoprotein 1 (LAMP1) is a transmembrane protein located on the lysosomal membrane that plays a key role in lysosome integrity, autophagy, and cellular homeostasis LAMP1 is highly expressed in cells undergoing autophagy, where it contributes to lysosomal stability and fusion with autophagosomes for the degradation of cellular waste It is involved in lysosome exocytosis, which regulates plasma membrane repair, pathogen clearance, and cellular stress responses LAMP1 also serves as a marker for lysosomal activity and has been implicated in immune responses, particularly in natural killer (NK) cell-mediated cytotoxicity Dysregulation of LAMP1 expression has been observed in neurodegenerative diseases such as Parkinson’s and Alzheimer’s, where impaired lysosomal function leads to protein aggregation and cellular toxicity Additionally, LAMP1 overexpression is associated with cancer progression and metastasis, where it facilitates cellular invasion through lysosome-mediated extracellular matrix degradation Its role in maintaining lysosomal function underscores its importance in cellular health and disease pathology
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