Lysosomal Associated Membrane Protein 2 (LAMP2) Antibody (PE)

Product specifications

Primary Antibodies

Lysosomal Associated Membrane Protein 2 (LAMP2)

Mouse

Human

FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user.

Monoclonal

PE

IgG1 Kappa

Z517

100 tests

FCM

Stabilizing PBS solution containing 15 mM sodium azide.

Shipped within 5-12 working days.

Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.

No

P13473

3920

CD107b,DND,LAMP-2,LAMPB,LGP-96,LGP110

Antibody anti-LAMP2

RUO

Descripción

Lysosome-associated membrane glycoprotein 2 (LAMP2) is a critical lysosomal membrane protein involved in autophagy, lysosomal biogenesis, and cellular homeostasis LAMP2 facilitates the fusion of autophagosomes with lysosomes, enabling the degradation of cellular components during autophagy LAMP2 exists in three isoforms (LAMP2A, LAMP2B, and LAMP2C), each with distinct roles in lysosome function LAMP2A is essential for chaperone-mediated autophagy (CMA), where it mediates the selective degradation of cytosolic proteins LAMP2B is primarily involved in macroautophagy, particularly in muscle and neuronal tissues Mutations in LAMP2 cause Danon disease, a rare lysosomal storage disorder characterized by cardiomyopathy, myopathy, and intellectual disability LAMP2 dysregulation has been linked to neurodegenerative diseases and cancers, where impaired autophagy disrupts cellular homeostasis and promotes disease progression LAMP2 also plays a role in immune responses, contributing to antigen processing and lysosomal exocytosis Its importance in autophagy, cellular stress responses, and disease underscores its critical role in maintaining cellular integrity

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