935106861
info@markelab.com
Precio
575€ (100 µg)
LAMP2 Antibody is a Rat Monoclonal against LAMP2.
Lysosome-associated membrane glycoprotein 2 (LAMP2) is a critical lysosomal membrane protein involved in autophagy, lysosomal biogenesis, and cellular homeostasis LAMP2 facilitates the fusion of autophagosomes with lysosomes, enabling the degradation of cellular components during autophagy LAMP2 exists in three isoforms (LAMP2A, LAMP2B, and LAMP2C), each with distinct roles in lysosome function LAMP2A is essential for chaperone-mediated autophagy (CMA), where it mediates the selective degradation of cytosolic proteins LAMP2B is primarily involved in macroautophagy, particularly in muscle and neuronal tissues Mutations in LAMP2 cause Danon disease, a rare lysosomal storage disorder characterized by cardiomyopathy, myopathy, and intellectual disability LAMP2 dysregulation has been linked to neurodegenerative diseases and cancers, where impaired autophagy disrupts cellular homeostasis and promotes disease progression LAMP2 also plays a role in immune responses, contributing to antigen processing and lysosomal exocytosis Its importance in autophagy, cellular stress responses, and disease underscores its critical role in maintaining cellular integrity
Primary Antibodies
Monoclonal
Human, Mouse, Rabbit
Lysosomal Associated Membrane Protein 2 (LAMP2)
Rat
Biotin
WB, IF/ICC, IP
Purified by Protein G.
PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
100 µg
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
LAMP2
No
Shipped within 5-12 working days.
CD107b,DND,LAMP-2,LAMPB,LGP-96,LGP110
NP_001017959.1
This product is for research use only.
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