Lysosomal Associated Membrane Protein 2 (LAMP2) Antibody
299€ (0.1 mg)
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935106861
info@markelab.com
name
Lysosomal Associated Membrane Protein 2 (LAMP2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139703
tested applications
WB, IHC, IF/ICC, FCM
Description
CD107b Antibody (Azide free) is a Mouse Monoclonal against CD107b.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Lysosomal Associated Membrane Protein 2 (LAMP2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1-2 μg/ml, IHC: 2-8 μg/ml, FCM: 1-2 μg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | Z517 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IHC, IF/ICC, FCM |
| Buffer | Azide free PBS, approx. pH 7.4; 0.2 µm filter sterilized. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P13473 |
| Gene ID | 3920 |
| Alias | CD107b,DND,LAMP-2,LAMPB,LGP-96,LGP110 |
| Background | Antibody anti-LAMP2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Lysosome-associated membrane glycoprotein 2 (LAMP2) is a critical lysosomal membrane protein involved in autophagy, lysosomal biogenesis, and cellular homeostasis LAMP2 facilitates the fusion of autophagosomes with lysosomes, enabling the degradation of cellular components during autophagy LAMP2 exists in three isoforms (LAMP2A, LAMP2B, and LAMP2C), each with distinct roles in lysosome function LAMP2A is essential for chaperone-mediated autophagy (CMA), where it mediates the selective degradation of cytosolic proteins LAMP2B is primarily involved in macroautophagy, particularly in muscle and neuronal tissues Mutations in LAMP2 cause Danon disease, a rare lysosomal storage disorder characterized by cardiomyopathy, myopathy, and intellectual disability LAMP2 dysregulation has been linked to neurodegenerative diseases and cancers, where impaired autophagy disrupts cellular homeostasis and promotes disease progression LAMP2 also plays a role in immune responses, contributing to antigen processing and lysosomal exocytosis Its importance in autophagy, cellular stress responses, and disease underscores its critical role in maintaining cellular integrity
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