Lysosomal Associated Membrane Protein 1 (LAMP1) Antibody
221€ (50 µg)
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Name
Lysosomal Associated Membrane Protein 1 (LAMP1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx330138
Tested Applications
ELISA, WB
Description
LAMP1 Antibody is a Rabbit Polyclonal against LAMP1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Lysosomal Associated Membrane Protein 1 (LAMP1) Immunogen: Synthesized peptide derived from the Internal region of human CD107a. |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11279 |
| Gene ID | 3916 |
| Alias | LAMPA,CD107a,LGP120,CD107 antigen-like family member A |
| Background | Antibody anti-LAMP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Lysosome-associated membrane glycoprotein 1 (LAMP1) is a transmembrane protein located on the lysosomal membrane that plays a key role in lysosome integrity, autophagy, and cellular homeostasis LAMP1 is highly expressed in cells undergoing autophagy, where it contributes to lysosomal stability and fusion with autophagosomes for the degradation of cellular waste It is involved in lysosome exocytosis, which regulates plasma membrane repair, pathogen clearance, and cellular stress responses LAMP1 also serves as a marker for lysosomal activity and has been implicated in immune responses, particularly in natural killer (NK) cell-mediated cytotoxicity Dysregulation of LAMP1 expression has been observed in neurodegenerative diseases such as Parkinson’s and Alzheimer’s, where impaired lysosomal function leads to protein aggregation and cellular toxicity Additionally, LAMP1 overexpression is associated with cancer progression and metastasis, where it facilitates cellular invasion through lysosome-mediated extracellular matrix degradation Its role in maintaining lysosomal function underscores its importance in cellular health and disease pathology
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