Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody

Name: Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody
Brand: Abbexa
SKU: abx230945
Price: 364 EUR
Availability: OnlineOnly

Pida mas información

935106861

info@markelab.com

Precio

364€ (100 µg)

Antibody anti-BRCC3

proveedor

Abbexa

reference

abx230945

Tested Applications

ELISA, WB, IHC, IP

reactivity

Human, Mouse, Rat, Monkey

status

RUO

clonality

Polyclonal

Descripción

Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody is a Rabbit Polyclonal against Lys-63-Specific Deubiquitinase BRCC36 (BRCC3). This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse, Rat, Monkey

immunogen target

Lys-63-Specific Deubiquitinase BRCC36 (BRCC3)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC, IP

purity

≥ 95% (SDS-PAGE)

purification

Purified by immunogen affinity chromatography.

recommended dilution

WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.

size 1

100 µg

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

BRCC3

dry ice

availability

Shipped within 5-12 working days.

uniprot id

https://www.uniprot.org/uniprotkb/P46736

gene id

https://www.ncbi.nlm.nih.gov/gene/79184

NCBI accession

NP_001018065.1, NM_001018055.2, NP_001229569.1, NM_001242640.1, NP_077308.1, NM_024332.3

note

Concentration: 2 mg/ml - Validity: 12 months.

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anti- BRCC3 antibody

proveedor

FineTest

reference

FNab00945

Tested Applications

ELISA, WB, IHC

reactivity

human,mouse,rat,monkey

status

RUO

clonality

polyclonal

Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains(PubMed:19214193, PubMed:20656690, PubMed:...

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