Lymphocyte Function Associated Antigen 3 / LFA-3 (CD58) Antibody (FITC)
429€ (100 tests)
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935106861
info@markelab.com
name
Lymphocyte Function Associated Antigen 3 / LFA-3 (CD58) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx413740
tested applications
FCM
Description
Lymphocyte Function-Associated Antigen 3 (CD58) Antibody (FITC) is a Mouse Monoclonal antibody against Lymphocyte Function-Associated Antigen 3 (CD58).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Lymphocyte Function Associated Antigen 3 / LFA-3 (CD58) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | FITC |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 100 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | Tris-buffered saline. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P19256 |
| Alias | ag3,LFA3,LFA-3,Lymphocyte function-associated antigen 3,Surface glycoprotein LFA-3 |
| Background | Antibody anti-CD58 |
| Status | RUO |
Descripción
CD58, also known as Lymphocyte Function-associated Antigen 3 (LFA-3), is a cell surface glycoprotein primarily involved in cell adhesion processes. It plays a critical role in the immune response by mediating the interaction between T cells and antigen-presenting cells (APCs). The CD58 protein is a member of the immunoglobulin (Ig) superfamily and is widely expressed on a variety of cell types, including epithelial cells, endothelial cells, lymphocytes, and dendritic cells. Its main binding partner is CD2, a receptor found on T cells and natural killer (NK) cells. This interaction is essential for the formation of the immune synapse, facilitating the activation of T cells and subsequent immune responses. CD58’s role is especially important in antigen presentation, where it helps T cells to recognize and respond to foreign antigens. The molecule is involved in co-stimulation during T-cell receptor (TCR) engagement, enhancing the immune system's ability to respond to pathogens, tumors, and other immunological challenges.
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Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and-dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
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