Lymphocyte Antigen 75 (LY75) Antibody
169€ (20 µl)
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935106861
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name
Lymphocyte Antigen 75 (LY75) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx322649
tested applications
ELISA, WB, IHC
Description
LY75 Antibody is a Rabbit Polyclonal against LY75.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Lymphocyte Antigen 75 (LY75) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60449 |
| Gene ID | 100526664, 4065 |
| NCBI Accession | NP_001185688.1, NM_001198759.1, NP_001185689.1, NM_001198760.1, NP_002340.2, NM_002349.3 |
| Alias | C-type lectin domain family 13 member B,CD205,LY-75,CLEC13B,DEC-205,GP200-MR6,Lymphocyte antigen 75 |
| Background | Antibody anti-LY75 |
| Status | RUO |
Descripción
LY75, also known as lymphocyte antigen 75, is a protein primarily involved in the immune system, specifically in antigen processing and presentation. LY75 is also referred to as DEC-205 (dendritic and epithelial cell 205) and is encoded by the LY75 gene in humans. LY75 belongs to the C-type lectin receptor family, which includes proteins involved in recognizing carbohydrate structures on pathogens, facilitating immune cell recognition, and initiating immune responses. It is a type I transmembrane protein highly expressed in dendritic cells (DCs), especially in lymphoid tissues, and also found on certain types of epithelial cells. Through its antigen-capturing ability, LY75 has a significant role in promoting immune tolerance and in the activation of T cells. LY75 functions as a receptor that binds to specific antigens, internalizes them, and processes them for presentation on major histocompatibility complex (MHC) molecules, primarily MHC class II. This makes it a critical component in activating adaptive immune responses, especially against infections, tumors, and other immune challenges. The ability of LY75 to capture and process antigens, combined with its expression pattern, positions it as an important target for immunotherapy, especially in contexts where modulation of the immune response, such as cancer immunotherapy and vaccine development, is desired.
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