Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Antibody
416€ (200 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432925
tested applications
P-ELISA, IF/ICC, FCM
Description
LHCGR Antibody is a Goat Polyclonal antibody against LHCGR.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IF/ICC, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 3973 |
| NCBI Accession | NP_000224.2 |
| Alias | LHCGR,Choriogonadotropin receptor,LCGR,LGR2,LHR, lutropin-choriogonadotropic hormone receptor,LH-R,Luteinizing Hormone/Choriogonadotropin Receptor, HHG,LH/CG-R,LH/CGR,LHR,LHRHR,LSH-R,ULG5 |
| Background | Antibody anti-LHCGR |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
LHCGR is a G protein-coupled receptor activated by luteinizing hormone (LH) and human chorionic gonadotropin (hCG), playing a crucial role in reproductive function. It is expressed in ovarian theca and granulosa cells in females and Leydig cells in males. In females, LHCGR regulates ovulation, corpus luteum formation, and progesterone production during the menstrual cycle and pregnancy. In males, LHCGR stimulates testosterone synthesis in Leydig cells, which supports spermatogenesis. LHCGR signaling activates adenylyl cyclase through Gs proteins, increasing cAMP levels and activating protein kinase A (PKA), which regulates steroidogenesis and cell proliferation. Mutations in LHCGR are linked to disorders such as precocious puberty, infertility, and hypogonadism. Overexpression of LHCGR has been observed in hormone-dependent cancers, including ovarian and testicular tumors, where it drives abnormal growth and survival. Therapeutically, LH/hCG analogs are used to treat infertility, while LHCGR antagonists are being explored for hormone-related cancers. LHCGR is vital for maintaining reproductive health and steroid hormone production.
Related Products
Human LHCGR(Lutropin-choriogonadotropic hormone receptor) ELISA Kit
Ver Producto
Mouse Lhcgr(Lutropin-choriogonadotropic hormone receptor) ELISA Kit
Ver Producto
anti- LHCGR antibody
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Ver Producto