LRP6 (pS1490) Antibody

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
LRP6 (pS1490) Antibody is a Rabbit Polyclonal against LRP6 (pS1490).
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | LRP6 (pS1490) |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | WB: 1/1000 - 1/3000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Purification | Purified by antigen affinity chromatography. |
Size 1 | 50 µl |
Size 2 | 100 µl |
Form | Liquid |
Tested Applications | WB |
Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | O75581 |
Gene ID | 4040 |
Background | Antibody anti-LRP6 |
Status | RUO |
Note | Concentration: 1 mg/ml - |
Descripción
Related Products

Human LRP6 (Low-density lipoprotein receptor-related protein 6) ELISA Kit
Ver Producto
Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Antibody
LRP6 Antibody is a Rabbit Polyclonal antibody against LRP6. This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Ver Producto
Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Antibody
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Ver Producto