Low Sample Volume Rat Suppressors Of Cytokine Signaling 1 (SOCS1) ELISA Kit

Este producto es parte de SOCS - Suppressor of cytokine signaling
Low Sample Volume Rat Suppressors Of Cytokine Signaling 1 (SOCS1) ELISA Kit
897€ (96 tests)

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Name
Low Sample Volume Rat Suppressors Of Cytokine Signaling 1 (SOCS1) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx572875
Tested Applications
ELISA

Description

Low Sample Volume Rat Suppressors Of Cytokine Signaling 1 (SOCS1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Suppressors Of Cytokine Signaling 1 (SOCS1) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Suppressors Of Cytokine Signaling 1 (SOCS1)

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Suppressors Of Cytokine Signaling 1 (SOCS1)
Reactivity
Rat
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.312 ng/ml - 20 ng/ml
Sensitivity
< 0.12 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
AISIMD,CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP-3,TIP3
Background
Elisa Kits for: SOCS1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

SOCS1 is a critical negative regulator of cytokine signaling pathways, particularly those mediated by the Janus kinase/signal transducer and activator of transcription (JAK/STAT) system. It functions by directly binding to JAKs through its SH2 domain and targeting them for proteasomal degradation via its SOCS box, which recruits components of the ubiquitin-proteasome machinery. SOCS1 regulates immune responses by preventing excessive cytokine signaling, particularly in interferon-γ, IL-6, and IL-4 pathways, ensuring proper immune homeostasis and inflammation control. It is highly expressed in immune cells, including T cells, macrophages, and dendritic cells, where it regulates processes like cytokine sensitivity, inflammation, and T-cell activation. Dysregulation of SOCS1 contributes to autoimmune diseases, chronic inflammation, and cancer due to hyperactivation of cytokine signaling. Knockout studies reveal severe inflammatory responses, lymphocyte activation, and neonatal lethality, underscoring its essential role in immune regulation and cytokine signaling balance.

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