Low Sample Volume Mouse Endoglin / CD105 (ENG) ELISA Kit
637€ (96 tests)
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935106861
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name
Low Sample Volume Mouse Endoglin / CD105 (ENG) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx573263
tested applications
ELISA
Description
Mouse Endoglin / CD105 (ENG) ELISA Kit is an ELISA kit against Mouse Endoglin / CD105 (ENG).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Endoglin / CD105 (ENG) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Sensitivity | < 0.47 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q63961 |
| Gene ID | 13805 |
| Alias | END,HHT1,ORW1,CD105 |
| Background | Elisa kits for ENG |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Endoglin, encoded by the ENG gene, is a key transmembrane glycoprotein in the TGF-β (transforming growth factor-beta) receptor complex, with significant roles in vascular development and endothelial cell biology. Also known as CD105, endoglin is crucial in angiogenesis and vascular homeostasis. It is prominently expressed on the surface of endothelial cells, especially in active angiogenic areas, as well as in other cell types like smooth muscle cells and some immune cells. Endoglin regulates cellular responses to TGF-β signaling, particularly within endothelial cells, which is essential for their proliferation, migration, and survival. Mutations in the ENG gene are linked to hereditary hemorrhagic telangiectasia type 1 (HHT1), a genetic disorder characterized by abnormal blood vessel formation, causing arteriovenous malformations, frequent nosebleeds, and other bleeding-related symptoms. Endoglin also plays a prominent role in cancer biology, where it can act as a biomarker for tumor angiogenesis. Its dual role in promoting normal vascular health and contributing to disease makes it an essential molecule in vascular biology research.
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