Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Antibody

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Antibody is a monoclonal Nanobody expressed in CHO cells for the detection of Human LRP6.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) |
Host | CHO cells |
Reactivity | Human |
Clonality | Monoclonal |
Conjugation | Unconjugated |
Isotype | VHH-8His-Cys-tag |
Clone ID | C862 |
Purity | > 95% (SDS-PAGE) |
Purification | Purified by Protein A/G affinity chromatography. |
Size 1 | 100 µg |
Size 2 | 1 mg |
Form | Liquid |
Tested Applications | ELISA |
Buffer | 0.01 M PBS, pH 7.4. |
Availability | Shipped within 5-12 working days. |
Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
Dry Ice | No |
UniProt ID | O75581 |
Gene ID | 4040 |
NCBI Accession | NP_002327.2 |
Background | Antibody anti-LRP6 |
Status | RUO |
Note | Concentration: 1 mg/ml - |
Descripción
Related Products

Human LRP6 (Low-density lipoprotein receptor-related protein 6) ELISA Kit
Ver Producto
Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Antibody
LRP6 Antibody is a Rabbit Polyclonal antibody against LRP6. This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Ver Producto
Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Antibody
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Ver Producto