Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Antibody

273€ (200 µl)
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935106861
info@markelab.com
name
Low Density Lipoprotein Receptor Related Protein 1 (LRP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431396
tested applications
P-ELISA
Description
LRP1 Antibody is a Goat Polyclonal antibody against LRP1.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Low Density Lipoprotein Receptor Related Protein 1 (LRP1) |
Host | Goat |
Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Size 1 | 200 µl |
Form | Liquid |
Tested Applications | P-ELISA |
Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Gene ID | 4035, 16971, 299858 |
NCBI Accession | NP_002323.2 |
Alias | Prolow-density lipoprotein receptor-related protein 1,Alpha-2-macroglobulin receptor,APR,KPA,LRP,A2MR,CD91; DDH3,APOER,LRP1A,TGFBR5,IGFBP3R,IGFBP-3R,IGFBP3R1,LRP-1,Apolipoprotein E receptor |
Background | Antibody anti-LRP1 |
Status | RUO |
Note | Concentration: 0.5 mg/ml - |
Descripción
Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) is a multifunctional cell surface receptor with diverse roles in cellular processes, including endocytosis, lipid transport, signal transduction, and the regulation of inflammation. Part of the low-density lipoprotein (LDL) receptor family, LRP1 has high sequence homology with the LDL receptor but a much broader set of ligands, facilitating interactions with various proteins, such as apolipoprotein E (ApoE), tissue plasminogen activator (tPA), and matrix metalloproteinases. LRP1 is highly expressed in the liver, brain, and adipose tissues, where it plays crucial roles in metabolism, neuroprotection, and vascular health. In neurons, LRP1 mediates neuroprotective processes and is implicated in the clearance of amyloid-beta, a key protein in Alzheimer’s disease pathology. In addition to metabolic and neural roles, LRP1 impacts cellular migration and adhesion, contributing to processes related to tissue injury repair, cancer metastasis, and inflammatory diseases. Its function and widespread expression make LRP1 a focal point in therapeutic research for conditions including neurodegenerative diseases, atherosclerosis, and certain cancers.
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