Low Density Lipoprotein Receptor Adaptor Protein 1 Protein
234€ (5 µg)
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name
Low Density Lipoprotein Receptor Adaptor Protein 1 Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx261903
tested applications
SDS-PAGE
Description
LDLRAP1 is a recombinant protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | LDLRAP1 |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | Q5SW96 |
| Alias | LDLRAP1, ARH, ARH1, ARH2, FHCB1, FHCB2, low density lipoprotein receptor adaptor protein 1, FHCL4 |
| Background | Protein LDLRAP1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Low-Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1), also known as ARH (autosomal recessive hypercholesterolemia protein), is a crucial adaptor protein that plays a pivotal role in the trafficking and internalization of low-density lipoprotein (LDL) receptors. It is predominantly expressed in hepatocytes and other tissues involved in cholesterol homeostasis. LDLRAP1 functions by linking the cytoplasmic tail of LDL receptors to clathrin-coated pits, facilitating receptor-mediated endocytosis of LDL particles. Mutations in the LDLRAP1 gene are associated with autosomal recessive hypercholesterolemia (ARH), a rare genetic disorder characterized by elevated plasma LDL cholesterol levels due to impaired clearance of LDL from circulation. This protein's interaction with other cellular components, such as AP-2 and clathrin, highlights its essential role in lipid metabolism and receptor recycling. As a significant contributor to cholesterol regulation, LDLRAP1 has been a subject of intense research, particularly for developing therapeutic strategies targeting cholesterol-related disorders.
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