Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) Antibody
169€ (20 µl)
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935106861
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name
Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx320231
tested applications
ELISA, IHC
Description
LDLRAP1 Antibody is a Rabbit Polyclonal against LDLRAP1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5SW96 |
| Gene ID | 26119 |
| OMIM | 603813 |
| Alias | LDLRAP1, ARH, ARH1, ARH2, FHCB1, FHCB2, low density lipoprotein receptor adaptor protein 1, FHCL4 |
| Background | Antibody anti-LDLRAP1 |
| Status | RUO |
Descripción
Low-Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1), also known as ARH (autosomal recessive hypercholesterolemia protein), is a crucial adaptor protein that plays a pivotal role in the trafficking and internalization of low-density lipoprotein (LDL) receptors. It is predominantly expressed in hepatocytes and other tissues involved in cholesterol homeostasis. LDLRAP1 functions by linking the cytoplasmic tail of LDL receptors to clathrin-coated pits, facilitating receptor-mediated endocytosis of LDL particles. Mutations in the LDLRAP1 gene are associated with autosomal recessive hypercholesterolemia (ARH), a rare genetic disorder characterized by elevated plasma LDL cholesterol levels due to impaired clearance of LDL from circulation. This protein's interaction with other cellular components, such as AP-2 and clathrin, highlights its essential role in lipid metabolism and receptor recycling. As a significant contributor to cholesterol regulation, LDLRAP1 has been a subject of intense research, particularly for developing therapeutic strategies targeting cholesterol-related disorders.
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