Lipopolysaccharide Binding Protein (LBP) Antibody
364€ (100 µg)
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935106861
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name
Lipopolysaccharide Binding Protein (LBP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx234713
tested applications
ELISA, WB
Description
LBP Antibody is a Rabbit Polyclonal against LBP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Lipopolysaccharide Binding Protein (LBP) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P18428 |
| Alias | BPIFD2,BPI Fold Containing Family D,LPS-Binding Protein 3 |
| Background | Antibody anti-LBP |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
LBP is an acute-phase protein produced mainly by the liver in response to infections and inflammation It plays a crucial role in innate immunity by binding to lipopolysaccharides (LPS) from the outer membrane of Gram-negative bacteria and delivering them to CD14 and Toll-like receptor 4 (TLR4) complexes on immune cells This process triggers signaling pathways that lead to the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, initiating immune defense against bacterial infections Elevated LBP levels are observed in sepsis, systemic inflammatory response syndrome (SIRS), and chronic inflammatory diseases Dysregulation of LBP contributes to endotoxemia, where excessive immune activation results in tissue damage and organ failure It is a valuable biomarker for assessing infection severity and therapeutic outcomes in sepsis and inflammatory conditions
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