Linker For Activation of T-Cells Family, Member 2 (LAT2) Antibody
442€ (200 µl)
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935106861
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name
Linker For Activation of T-Cells Family, Member 2 (LAT2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432916
tested applications
P-ELISA, WB, IF/ICC, FCM
Description
LAT2 Antibody is a Goat Polyclonal antibody against LAT2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Linker For Activation of T-Cells Family, Member 2 (LAT2) Immunogen: abx617041 - Internal region: C-RSEKIYQQRSLRED |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IF/ICC, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 7462 |
| NCBI Accession | NP_054865.2 |
| Alias | LAT2,LAB, NTAL, WBSCR15, WBSCR5, WSCR5, HSPC046 |
| Background | Antibody anti-LAT2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Linker for activation of T-cells family member 2 (LAT2), also known as NTAL (Non-T cell Activation Linker), is an adaptor protein expressed in various immune cells, including B cells, mast cells, and NK cells. LAT2 functions analogously to LAT by facilitating signal transduction from immunoreceptors, such as the B-cell receptor (BCR) and Fc receptors, to downstream signaling cascades. Upon receptor engagement, LAT2 undergoes tyrosine phosphorylation, enabling it to recruit signaling molecules, such as Grb2 and PLCγ, which are essential for calcium mobilization and activation of the MAPK pathway. LAT2 plays a crucial role in immune responses, particularly in B-cell activation, mast cell degranulation, and cytokine production. Unlike LAT, LAT2 exhibits a broader expression pattern and participates in both adaptive and innate immunity. Its dysregulation has been implicated in allergic reactions and immune cell hyperactivity, making it a potential therapeutic target in allergic and inflammatory diseases.
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