LIM Domain Kinase 2 (LIMK2) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
LIMK2 Antibody is a Rabbit Polyclonal against LIMK2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | LIM Domain Kinase 2 (LIMK2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P53671 |
| Gene ID | 3985 |
| NCBI Accession | NP_001026971.1, NM_001031801.1, NP_005560.1, NM_005569.3 |
| OMIM | 601988 |
| Background | Antibody anti-LIMK2 |
| Status | RUO |
Descripción
Related Products
LIMK2 antibody
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone(MBP) in vitro.
Ver Producto
Recombinant Human LIMK2
Ver Producto
LIMK2 (pT505) Antibody
LIMK2 (pT505) Antibody is a Rabbit Polyclonal antibody against LIMK2 (pT505). There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
Ver Producto