Leukocyte Surface Antigen CD47 (CD47) Antibody (Biotin)
78€ (25 µg)
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Name
Leukocyte Surface Antigen CD47 (CD47) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx228208
Tested Applications
FCM
Description
CD47 Antibody (Biotin) is a Human, Mouse, Rat Monoclonal Antibody against CD47.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Leukocyte Surface Antigen CD47 (CD47) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Conjugation | Biotin |
| Isotype | IgG1 |
| Size 1 | 25 µg |
| Size 2 | 100 µg |
| Tested Applications | FCM |
| Buffer | PBS with 0.05% Proclin300, 1% BSA. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q08722, Q61735, P97829 |
| Gene ID | 961, 16423, 29364 |
| OMIM | 601028 |
| Alias | IAP,OA3,MER6,Antigenic surface determinant protein OA3,Integrin-associated protein, |
| Background | Antibody anti-CD47 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD47, also known as integrin-associated protein (IAP), is a widely expressed transmembrane glycoprotein that plays a critical role in immune regulation, cell signaling, and cellular adhesion. It is a member of the immunoglobulin superfamily and is involved in numerous biological processes, including immune evasion, apoptosis, angiogenesis, and cell migration. One of CD47's primary functions is to act as a "don't eat me" signal to prevent macrophage-mediated phagocytosis, which is a key component in the immune system's ability to clear dead cells and pathogens. CD47 interacts with signal regulatory protein alpha (SIRPα), a receptor primarily expressed on myeloid cells, such as macrophages and dendritic cells. The binding of CD47 to SIRPα sends an inhibitory signal to macrophages, preventing the phagocytosis of CD47-expressing cells. This interaction plays a critical role in protecting normal cells from immune clearance but can also be exploited by cancer cells to evade immune detection and destruction.
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