Leukocyte Immunoglobulin Like Receptor A4 (LILRA4) Antibody

Background

LILRA4 (Leukocyte Immunoglobulin-Like Receptor A4), also known as ILT7 or CD85g, is a member of the leukocyte immunoglobulin-like receptor (LILR) family, which is primarily involved in modulating immune responses. This receptor family is part of the Leukocyte Receptor Complex (LRC) on chromosome 19q13.4, where several LILR family members are located, often associated with immune regulation. LILRA4 is distinct among LILRs as it is uniquely expressed on plasmacytoid dendritic cells (pDCs), a specialized dendritic cell subset primarily responsible for antiviral responses and producing type I interferons in response to viral infection. LILRA4 plays a suppressive role on pDCs by modulating interferon production, impacting immune responses, and helping maintain immune homeostasis. The regulation of interferon responses by LILRA4 is crucial, particularly because excessive interferon production can contribute to inflammatory and autoimmune disorders