Leukocyte Elastase Inhibitor (SERPINB1) Antibody
292.5€ (80 µl)
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935106861
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name
Leukocyte Elastase Inhibitor (SERPINB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028623
tested applications
ELISA, WB
Description
SERPINB1 regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leukocyte Elastase Inhibitor (SERPINB1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30740 |
| Alias | EI,LEI,PI2,MNEI,PI-2,HEL57,M/NEI,ELANH2,HEL-S-27,Leukocyte elastase inhibitor,Monocyte/neutrophil elastase inhibitor,Peptidase inhibitor 2,Serpin B1 |
| Background | Antibody anti-SERPINB1 |
| Status | RUO |
Descripción
SERPINB1, also known as leukocyte elastase inhibitor or monocyte neutrophil elastase inhibitor, is a member of the serine protease inhibitor (SERPIN) family. The SERPIN superfamily is one of the largest and most diverse groups of protease inhibitors, playing a crucial role in regulating various physiological processes, including inflammation, apoptosis, and immune responses. Unlike many SERPINs that inhibit proteases through a suicide substrate-like mechanism involving the formation of a covalent complex, SERPINB1 acts primarily in the intracellular environment to protect cells from protease-mediated damage. SERPINB1 is encoded by the SERPINB1 gene located on chromosome 6p25 in humans. This gene belongs to the SERPINB clade, which is a subgroup of the SERPIN family predominantly found in the cytoplasm rather than being secreted
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