Leukemia Inhibitory Factor Receptor Alpha (LIFR) Antibody

Este producto es parte de LIFR - LIF receptor subunit alpha
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364€ (100 µg)

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935106861
info@markelab.com
name
Leukemia Inhibitory Factor Receptor Alpha (LIFR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx234773
tested applications
ELISA, WB, IHC, IF/ICC

Description

LIFR Antibody is a Rabbit Polyclonal against LIFR.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Leukemia Inhibitory Factor Receptor Alpha (LIFR)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500 - 1/1000, IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by immunogen affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P42702
Gene ID
3977
Alias
Leukemia inhibitory factor receptor,SWS,SJS2,STWS,CD118,LIF-R,LIF receptor
Background
Antibody anti-LIFR
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

The leukemia inhibitory factor receptor (LIFR), also known as the LIF receptor subunit alpha, is a component of a cytokine receptor complex responsible for mediating the effects of the leukemia inhibitory factor (LIF). LIF is part of the interleukin-6 (IL-6) family of cytokines and is involved in various cellular processes, such as cell survival, proliferation, and differentiation, particularly in neuronal, hematopoietic, and reproductive cells. LIFR is encoded by the LIFR gene, located on chromosome 5p13, and is widely expressed across various tissues, including the placenta, brain, liver, and bone marrow. LIFR functions as a non-signaling receptor subunit and, upon binding to LIF, associates with the co-receptor gp130. Together, this receptor complex initiates intracellular signaling pathways that are central to immune responses, tissue repair, and neural development. LIFR is significant in embryonic development and stem cell maintenance, and dysregulation of LIFR signaling is associated with several diseases, such as inflammatory disorders, cancer, and neurodegenerative diseases.

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