Large Proline-Rich Protein BAG6 (BAG6) Antibody
169€ (20 µl)
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Name
Large Proline-Rich Protein BAG6 (BAG6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx320584
Tested Applications
ELISA, IHC
Description
BAG6 Antibody is a Rabbit Polyclonal against BAG6.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Large Proline-Rich Protein BAG6 (BAG6) Immunogen: Recombinant human Large proline-rich protein BAG6 protein (1-200AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P46379 |
| Gene ID | 7917 |
| NCBI Accession | NP_001092004.1, NM_001098534.1, NP_001186626.1, NM_001199697.1, NP_001186627.1, NM_001199698.1, NP_004630.3, NM_004639.3 |
| OMIM | 142590 |
| Alias | BAG-6,BAT3,D6S52E,G3,BCL2-associated athanogene 6,HLA-B-associated transcript 3,BAG family molecular chaperone regulator 6 |
| Background | Antibody anti-BAG6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
BAG cochaperone 6 (BAG6) is a protein that interacts with the HSP70 chaperone to regulate the turnover and degradation of misfolded proteins, playing a critical role in the cellular response to stress BAG6 is involved in maintaining cellular protein homeostasis, particularly in the degradation of unstable proteins through the ubiquitin-proteasome pathway It helps in protein quality control by preventing the accumulation of damaged or misfolded proteins, which can otherwise lead to cellular dysfunction BAG6 also regulates autophagy, a process through which cells degrade and recycle damaged proteins and organelles under stress conditions In cancer, BAG6 has been implicated in modulating apoptosis and promoting tumor cell survival by stabilizing key signaling proteins Dysregulation of BAG6 expression is linked to neurodegenerative diseases and heart disease, where defective protein turnover contributes to tissue damage and dysfunction BAG6’s involvement in stress responses, autophagy, and protein degradation highlights its importance in maintaining cellular health and stability
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