Large Neutral Amino Acid Transporter 1 / LAT1 (SLC7A5) Antibody
416€ (200 µl)
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name
Large Neutral Amino Acid Transporter 1 / LAT1 (SLC7A5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430256
tested applications
P-ELISA, WB
Description
Large Neutral Amino Acid Transporter 1 / LAT1 (SLC7A5) Antibody is a Goat Polyclonal antibody against Large Neutral Amino Acid Transporter 1 / LAT1 (SLC7A5).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Large Neutral Amino Acid Transporter 1 / LAT1 (SLC7A5) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 8140 |
| NCBI Accession | NP_003477.4 |
| Alias | Large neutral amino acids transporter small subunit 1,4F2 light chain,E16,CD98,LAT1,4F2LC,MPE16,D16S469E,CD98 light chain,Integral membrane protein E16 |
| Background | Antibody anti-SLC7A5 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
SLC7A5, also known as LAT1 (L-type amino acid transporter 1), is a transmembrane protein crucial for amino acid transport across the plasma membrane. It is part of the solute carrier family 7 (SLC7), specifically associated with the transport of large neutral amino acids (LNAAs) like leucine, isoleucine, valine, phenylalanine, and tryptophan, which are essential for various cellular functions. LAT1 is a high-affinity, sodium-independent transporter and functions as part of a heteromeric complex with SLC3A2 (4F2hc or CD98), which acts as a chaperone protein for the proper membrane localization and functionality of LAT1. SLC7A5 plays a significant role in cellular growth and proliferation, and it is highly expressed in rapidly dividing cells. It is abundant in tissues with high metabolic demands, such as the brain, placenta, and certain immune cells, as well as in many cancer cell types, where it facilitates the increased amino acid demand required for protein synthesis and tumor growth. LAT1 is also integral to the blood-brain barrier, as it enables the transport of essential amino acids into the brain, thereby impacting neurotransmitter synthesis.
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