Lactate Dehydrogenase A (LDHA) Antibody
169€ (20 µg)
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name
Lactate Dehydrogenase A (LDHA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx109970
tested applications
ELISA, WB, IHC, IF/ICC
Description
L-lactate dehydrogenase A chain Antibody is a Rabbit Polyclonal antibody against L-lactate dehydrogenase A chain.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Lactate Dehydrogenase A (LDHA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P00338 |
| Gene ID | 3939 |
| NCBI Accession | NP_001128711.1, NM_001135239.1 |
| OMIM | 150000 |
| Alias | LDHM, GSD11,PIG1,HEL-S-133P,lactate Dehydrogenase A,prolifeRation-inducing gene 19 |
| Background | Antibody anti-LDHA |
| Status | RUO |
Descripción
Lactate Dehydrogenase A (LDHA) is an enzyme that catalyzes the conversion of pyruvate to lactate in the final step of anaerobic glycolysis. LDHA plays a critical role in cellular energy metabolism, especially under hypoxic conditions, where it helps regenerate NAD+ for glycolysis. It is highly expressed in tissues with high glycolytic activity, such as skeletal muscle. In cancer, LDHA is upregulated as part of the Warburg effect, where tumor cells preferentially use glycolysis for energy production, even in the presence of oxygen. Elevated LDHA expression is associated with tumor growth, metastasis, and resistance to therapy, making it a target for anticancer therapies. Beyond cancer, LDHA is implicated in metabolic disorders and muscular diseases, highlighting its importance in both normal physiology and pathological conditions.
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