KISS1R-Specific Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
KISS1R-Specific Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx234593
tested applications
ELISA, WB, IHC, IF/ICC
Description
KISS1R-Specific Antibody is a Rabbit Polyclonal against KISS1R-Specific.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | KISS1R-Specific |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q969F8 |
| Gene ID | 84634 |
| Alias | KISS1R,GPR54,Metastin receptor,hOT7T175,kiSS-1 receptor,kiSS-1R,KiSS1-derived peptide receptor |
| Background | Antibody anti-KISS1R |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
KISS1R, also known as GPR54, is a G protein-coupled receptor activated by kisspeptins, a family of peptide ligands derived from the KISS1 gene. KISS1R plays a crucial role in regulating the hypothalamic-pituitary-gonadal (HPG) axis, particularly in puberty onset and reproductive function. It is highly expressed in the hypothalamus, where kisspeptin signaling stimulates the secretion of gonadotropin-releasing hormone (GnRH), which in turn regulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. This pathway is essential for normal sexual maturation, fertility, and reproductive hormone balance. Mutations in KISS1R are associated with hypogonadotropic hypogonadism, delayed puberty, and infertility. Beyond reproduction, KISS1R signaling is implicated in metastasis suppression, as kisspeptins inhibit cell migration and invasion in cancers such as melanoma and breast cancer. Dysregulation of KISS1R has also been linked to metabolic disorders and polycystic ovary syndrome (PCOS). Therapeutically, KISS1R agonists and antagonists are being explored for treating infertility, hormone-driven cancers, and reproductive disorders.
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