Kinase Insert Domain Receptor Phospho-Tyr1214 (KDR pY1214) Antibody
429€ (100 µl)
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935106861
info@markelab.com
name
Kinase Insert Domain Receptor Phospho-Tyr1214 (KDR pY1214) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx332977
tested applications
ELISA, WB, IHC, IF/ICC
Description
KDR (pY1214) Antibody is a Rabbit Polyclonal against KDR (pY1214).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Kinase Insert Domain Receptor Phospho-Tyr1214 (KDR pY1214) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr1214 |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35968 |
| Gene ID | 3791 |
| Alias | FLK1,CD309,VEGFR,VEGFR2,VEGFR-2,Protein-tyrosine kinase receptor flk-1,Fetal liver kinase 1,Vascular endothelial growth factor receptor 2 |
| Background | Antibody anti-KDR |
| Status | RUO |
Descripción
KDR, also known as vascular endothelial growth factor receptor 2 (VEGFR-2), is a critical protein in the regulation of angiogenesis and vascular development. This receptor tyrosine kinase (RTK) is encoded by the KDR gene located on chromosome 4q12 in humans. KDR is a member of the VEGF receptor family, which plays an essential role in the processes of vasculogenesis and angiogenesis by mediating the cellular responses to the vascular endothelial growth factor (VEGF). The VEGF family consists of several ligands, with VEGF-A being the primary ligand for KDR. KDR is predominantly expressed in endothelial cells, where it regulates vascular permeability, endothelial cell proliferation, migration, and survival. Due to its pivotal role in vascular biology, KDR has been extensively studied in the context of cancer, where angiogenesis is a crucial process for tumor growth and metastasis. KDR's involvement in pathological angiogenesis makes it a significant target for anti-angiogenic therapies in cancer treatment. Moreover, it has implications in other diseases characterized by abnormal vascular growth, such as age-related macular degeneration and rheumatoid arthritis.
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