Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) Antibody (Biotin)
169€ (20 µg)
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Name
Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx343676
Tested Applications
ELISA
Description
Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human KIR2DL2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) Immunogen: Recombinant Human Killer cell immunoglobulin-like receptor 2DL2 protein (22-245 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43627 |
| Alias | CD158 antigen-like family member B1,Natural killer-associated transcript 6,NKAT6,p58.2,CD158b,NKAT-6,CD158B1 |
| Background | Antibody anti-KIR2DL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Killer cell immunoglobulin-like receptors (KIRs) are a family of proteins primarily expressed on the surface of natural killer (NK) cells and some T-cell subsets. KIR2DL2, a member of this family, plays an essential role in regulating NK cell function and contributes to immune surveillance and self-tolerance mechanisms. KIR2DL2 is an inhibitory receptor that recognizes specific human leukocyte antigen (HLA) class I molecules on target cells, allowing NK cells to modulate their activity in response to changes in HLA expression, which often occur in cells affected by infection, cancer, or other pathological states. KIR2DL2’s primary role is to suppress NK cell activity upon binding to its specific HLA ligand, which reduces the likelihood of NK cell-mediated destruction of healthy cells displaying self-HLA markers. The genes encoding KIR proteins, including KIR2DL2, are located on chromosome 19q13.4 within the leukocyte receptor complex (LRC). KIR genes are highly polymorphic, with significant inter-individual variability in gene content and sequence. This variability contributes to an individual’s unique immune response capacity, as well as to population-level diversity in immune defense. The primary ligand for KIR2DL2 is HLA-C, specifically the HLA-C1 epitope (characterized by the presence of asparagine at position 80), which is distinct from the HLA-C2 epitope (lysine at position 80) recognized by other KIR molecules like KIR2DL1.
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