Keratin, Type II Cytoskeletal 8 (KRT8) Antibody (FITC)
364€ (0.1 mg)
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Name
Keratin, Type II Cytoskeletal 8 (KRT8) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139679
Tested Applications
FCM
Description
Cytokeratin 8 Antibody is a Mouse Monoclonal against Cytokeratin 8.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Keratin, Type II Cytoskeletal 8 (KRT8) Immunogen: Cytoskeleton preparation from HeLa Human cervix carcinoma cell line. |
| Host | Mouse |
| Reactivity | Human, Pig, Rabbit, Cow, Sheep |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | FCM: 1-2 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | FITC |
| Isotype | IgG1 |
| Clone ID | C416 |
| Size 1 | 0.1 mg |
| Tested Applications | FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q7L4M3 |
| Gene ID | 3856 |
| Alias | K8,KO,CK8,CK-8,CYK8,K2C8,CARD2,Cytokeratin-8,Keratin-8,Type-II keratin Kb8 |
| Background | Antibody anti-KRT8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Keratin 8 (KRT8) is a type II intermediate filament protein primarily expressed in simple epithelial tissues, including the gastrointestinal tract, liver, and lungs, where it provides mechanical support and structural stability to epithelial cells KRT8 pairs with keratin 18 (KRT18) to form heterodimers that assemble into intermediate filaments, maintaining cytoskeletal integrity and cell resilience under mechanical and chemical stress KRT8 is involved in cell signaling, apoptosis, and protection against oxidative stress, contributing to epithelial cell survival Dysregulation or mutations in KRT8 are associated with liver diseases such as steatohepatitis, cirrhosis, and hepatocellular carcinoma, where KRT8 aggregates can impair cellular function KRT8 also participates in tumorigenesis by promoting epithelial-mesenchymal transition (EMT), enhancing cancer cell migration, invasion, and metastasis Elevated KRT8 expression is observed in various cancers, including colorectal, breast, and pancreatic cancer, where it serves as a diagnostic marker for disease progression and prognosis
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