Kell Protein (KEL) Antibody

Este producto es parte de KEL - Kell metallo-endopeptidase
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169€ (20 µg)

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935106861
info@markelab.com
name
Kell Protein (KEL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx302719
tested applications
ELISA, WB, IHC

Description

KEL Antibody is a Rabbit Polyclonal against KEL.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Kell Protein (KEL)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P23276
Gene ID
3792
OMIM
110900
Alias
Kell blood group glycoprotein,ECE3,Kell,CD238,
Background
Antibody anti-KEL
Status
RUO

Descripción

Kell (KEL), also known as Kell metallo-endopeptidase, is a membrane-bound glycoprotein found primarily on the surface of red blood cells (RBCs). It is a key player in the Kell blood group system, which is one of the most important blood group systems for transfusion medicine. The Kell blood group system includes various antigens, with the K (K1) and k (K2) antigens being the most clinically significant. These antigens are carried by the Kell protein, and variations in the expression of these antigens are associated with immune reactions in transfusion therapy and hemolytic disease of the newborn (HDN). Kell is also a metalloendopeptidase, which means it has enzymatic activity and is capable of cleaving peptide bonds in substrates, a function typical of certain metalloproteins. The Kell protein is involved in regulating the function and integrity of red blood cells, and it also plays a role in the interaction of the RBC with the immune system. Despite its primary association with blood group antigens, Kell is part of a larger group of proteins with endopeptidase activity. The protein is encoded by the KEL gene, located on the X chromosome (Xp21.1). This gene is expressed at high levels in erythroid precursor cells and mature erythrocytes, with its most significant role being the expression of the Kell antigens.

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