Kell Protein (KEL) Antibody

Este producto es parte de KEL - Kell metallo-endopeptidase
Kell Protein (KEL) Antibody

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935106861

info@markelab.com

Precio

195€ (20 µl)

Antibody anti-KEL

proveedor

Abbexa

reference

abx136026

Tested Applications

ELISA, WB

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

KEL Antibody is a Rabbit Polyclonal against KEL.


Background

Kell (KEL), also known as Kell metallo-endopeptidase, is a membrane-bound glycoprotein found primarily on the surface of red blood cells (RBCs). It is a key player in the Kell blood group system, which is one of the most important blood group systems for transfusion medicine. The Kell blood group system includes various antigens, with the K (K1) and k (K2) antigens being the most clinically significant. These antigens are carried by the Kell protein, and variations in the expression of these antigens are associated with immune reactions in transfusion therapy and hemolytic disease of the newborn (HDN). Kell is also a metalloendopeptidase, which means it has enzymatic activity and is capable of cleaving peptide bonds in substrates, a function typical of certain metalloproteins. The Kell protein is involved in regulating the function and integrity of red blood cells, and it also plays a role in the interaction of the RBC with the immune system. Despite its primary association with blood group antigens, Kell is part of a larger group of proteins with endopeptidase activity. The protein is encoded by the KEL gene, located on the X chromosome (Xp21.1). This gene is expressed at high levels in erythroid precursor cells and mature erythrocytes, with its most significant role being the expression of the Kell antigens.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Kell Protein (KEL)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB


purification

Purified by affinity chromatography.


recommended dilution

ELISA: 1 µg/ml, WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.


size 1

20 µl


size 2

100 µl


size 3

2 × 100 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

KEL


dry ice

No


availability

Shipped within 5-10 working days.


alias

Kell blood group glycoprotein,ECE3,Kell,CD238,


NCBI accession

NP_000411.1


note

Concentration: > 0.2 mg/ml -


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