Kell Protein (KEL) Antibody

273€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Kell Protein (KEL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130812
tested applications
WB, IHC, IF/ICC
Description
Kell Protein Antibody is a Rabbit Polyclonal against Kell Protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Kell Protein (KEL) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
Size 1 | 100 µl |
Size 2 | 200 µl |
Size 3 | 1 ml |
Form | Liquid |
Tested Applications | WB, IHC, IF/ICC |
Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
Availability | Shipped within 5-7 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | Kell blood group glycoprotein,ECE3,Kell,CD238, |
Background | Antibody anti-KEL |
Status | RUO |
Descripción
Kell (KEL), also known as Kell metallo-endopeptidase, is a membrane-bound glycoprotein found primarily on the surface of red blood cells (RBCs). It is a key player in the Kell blood group system, which is one of the most important blood group systems for transfusion medicine. The Kell blood group system includes various antigens, with the K (K1) and k (K2) antigens being the most clinically significant. These antigens are carried by the Kell protein, and variations in the expression of these antigens are associated with immune reactions in transfusion therapy and hemolytic disease of the newborn (HDN). Kell is also a metalloendopeptidase, which means it has enzymatic activity and is capable of cleaving peptide bonds in substrates, a function typical of certain metalloproteins. The Kell protein is involved in regulating the function and integrity of red blood cells, and it also plays a role in the interaction of the RBC with the immune system. Despite its primary association with blood group antigens, Kell is part of a larger group of proteins with endopeptidase activity. The protein is encoded by the KEL gene, located on the X chromosome (Xp21.1). This gene is expressed at high levels in erythroid precursor cells and mature erythrocytes, with its most significant role being the expression of the Kell antigens.
Related Products

Recombinant Human Kell
Ver Producto
Kell Protein (KEL) Antibody
This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.
Ver Producto
Kell Protein (KEL) Antibody
Kell Protein Antibody is a Rabbit Polyclonal against Kell Protein.
Ver Producto